|
|
|
|
A1¥N½X¡G6_45200.5792592593-5695 ¤Þ¥Î
A1¥N½X¡G6_44349.7049305556-2306 ¤Þ¥Î
|
¬r³D«r¶Ë»P§Ü³D¬r¦å²Mµo®i·§ªp
ªþ¥ó¡G
¬r³D«r¶Ë»P§Ü³D¬r¦å²Mµo®i·§ªp¦Û¥j¥H¨Ó¡A¤H̹ï³Dªº¦L¶H¡A´N¬O·|«r¤Hn·q¦Ó»·¤§¡Cð´Â¤å¾Ç®aÁú·U¼gµ¹¦n¤Í±i¸p¡m¤K¤ë¤Q¤©]Ãرi¥\±ä¡nªº¸Öµü¤¤§Y´£¨ì¡G¡u¤UþH¬È³D¹¬ÈÃÄ¡A®ü®ð·ÃîhÂȸ{íë¡C¡v°£¤F´yz¤@¯ë±f¥Á¹ï³Dªº¬ÈÄߤ§¤ß¡A¤]ÂI¥X®ðÔ·Å·x¼éÀ㪺¤¤°ê«n¤è¡]«nÆZ¡^¬O³DÃþ´Ï®§¤§¦a¡C¨´¤µ¡A¥þ²y¤wµo²{¶W¹L¤T¤dÓ¤£¦Pªº³DºØ¡A¦³ªñ¤»¦ÊºØ¬°¦³¬r³DÃþ¡A¦h¼Æ´Ï®§¦b¼ö±a»P¨È¼ö±a¦a°Ï¡C¨Ì¾Ú¥@¬É½Ã¥Í²Õ´¡]WHO¡^³Ì·sªº¸ê®Æ²Îp¡A¨C¦~¬ù¦³¤@¦Ê¤K¤Q¦Ü¤G¦Ê¤C¤Q¸UÓ³D¶Ë®×¥ó¡A¨Ã³y¦¨8.1¦Ü13.8¸U¤H¦º¤`¡AƦsªÌ¦h¥b¤]¯d¤U¥Ã¤[©Êªº´Ý¯e¡AÅã¥Ü¬r³D«r¶Ë¦b¼ö±a¤Î¨È¼ö±a°Ï°ì¬O¤@ÓÄY«ªº¤½¦@¦w¥þijÃD¡C §Ü³D¬r¦å²M¬OWHO«Øij¥Î©óªvÀø¬r³D«r¶Ëªº»s¾¯¡C¦å²M»s¾¯¤¤¥Dn¦¨¤À¬°§K¬Ì²y³J¥Õ¡A«UºÙ§ÜÅé¡A¯à¦³®Ä¦a»P¬r¯Àµ²¦X¥H½w¸Ñ³D¬r¦b±wªÌÅ餺¤Þ°_ªº¯gª¬¡C§Ü³D¬r¦å²Mµo®iªº¾ú¥v¡A³Ì¦¥i¥H¦^·¹¦Ü1887¦~¡AHenry Sewall±NÂF¤l·P¬V縳Dªº³D¬r»s§@¥X¥þ¥@¬É²Ä¤@ӧܳD¬r¦å²M[1]¡C1894¦~¡A¤Ú´µ¼w¬ã¨s©ÒªºAlbert CalmetteÂå®v«h¬O²Ä¤@¦ì¥Ñ°¨¤Ç§K¬Ì³D¬r»s³Æ¥X¦³®Äªº§Ü³D¬r¦å²M¡A¨Ã¦¨¥\¦aªv¡³Q²´Ãè³D«r¶Ëªº±wªÌ[2]¡C¤@Ó¥@¬ö¥H¨Ó¡A¦å²Mªº»sµ{¤]¸g¹L¤@¨t¦CÀu¤Æ¡A¥Ñ³Ì¦´Á²Ê»sªº§Ü¦å²M¡A¥[¤J´£¤É§ÜÅé¯Â«×ªºÆQªR¯Â¤Æ¨BÆJ¡A«áÄò§Q¥Î¯Ø³J¥Õ酶¥h°£FcºÝªº§Î¦¨³æªÑFab©ÎÂùªÑF¡]ab¡¦¡^2§ÜÅé¤ù¬q¡A¤j´T§ïµ½¨äªvÀø®ÄªG¤Î²£¶q¡C¦]¦¹¡A§Ü³D¬r¦å²M»s³y¹Lµ{¬Û·íÁcº¾¥B³y»ù¤£´´¡A§ó¹N½×¬r³Dªº°é¾i¥H¤Î³D¬rªº±Ä¶°§ó¼W²K¤F¦å²M»s§@ªº¦¨¥»»P½ÆÂø«×¡C¥Ø«e¡A¥þ²y¬ù¦³¥|¤Q¤»Ó¦å²M»s³y³æ¦ì¡A¦ýWHO¦ôp¨C¦~¬ù»Ý¤@¤d¸U¾¯ªº§Ü³D¬r¦å²M¡A¨ÑÀ³¤£¨¬»P°ª©ùªº»ù®æ¨Ï³D¶Ë±wªÌ¦b¨ú±o§Ü³D¬r¦å²M¤W²£¥Í§xÃø»P²~ÀV¡C¦]¦¹¡AWHO©ó2017¦~±N¬r³D«r¶Ë¦C¬°³Q©¿²¤ªº¼ö±a¯e¯f¤§¤@¡]neglect tropical diseases¡A NTD¡^¡A¦P®É¤]±N§Ü³D¬r¦å²M»s¾¯¦C¬°¼ö±a¦a°Ï°ê®a¥²³Æ¤§°ò¥»ÃÄ«~¡C ¶Ç²Îªº§Ü³D¬r¦å²M¬O¥H¨ú±o³D¬r§@¬°§K¬Ìì»s³Æ¦Ó¦¨¡FµM¦Ó¡A¨ú±o³o¨Ç³D¬rªº¹Lµ{¤£¦ý·ÀI·¥°ª¡A¥B«O¦s¤£©ö¡C¥Ø«e¬ã¨s¤Hû¶}µo·s«¬§K¬Ìì¥H¨ú¥N¶Ç²Î³D¬r¡A¥]§t¦X¦¨Ð`肽¡B«²Õ¡]Ãþ¡^¬r¯À¡B¦@¦³¬r¯À»PDNAÁåµ¥¡C¥Ñ©ó¥u°w¹ï§K¬Ìì¶i¦æ§ïÅÜ¡A§Q¥Î´À¥N§K¬Ìì¥Í²£ªº°¨¦å²M¥iª½±µ»P²{¦æ§Ü³D¬r¦å²M»sµ{±µy¡A¦¨«~¤]¸û©ö³Qªk³W±µ¨ü¡CÁ|¨Ò¦Ó¨¥¡A¬ì¾Ç®a°w¹ï縳D³D¬rªº¥Dn¬r¯À¡]myotoxin©Mmutalysin ii¡^¿z¿ï¥Xªº§Üìªí¦ì¡]epitopes¡^¡A¦X¦¨¥XÐ`肽§@¬°§K¬Ìì¡A°Êª«¹êÅçµ²ªGÅã¥Ü¡A¥i¥H²£¥Í¦³®Äªº§ÜÅ餤©M²ÊÅì¥ÙÀY縡]Bothrops asper¡^¦Ù¦×¬r©Ê[3]¥H¤Î«n¬ü¥¨ç¸¡]Lachesis muta¡^³D¬r©Ò³y¦¨ªº¥X¦å¬r©Ê[4]¡C¬Û¦Pªº·§©À¤]¾A¥Î©ó¯«¸g¬r©Êªº³D¬r¡CDolimbek³Õ¤hµ¥¤Hµo²{¡A¤p¹«¥H«B³Ê¸`³D¬r·í¤¤P¦º©Ê³Ì°ªªºbungarotoxinªº3¬q¦X¦¨§Üìªí¦ì§K¬Ì«á¡A¥i¥H©Ó¨üÀR¯ßª`®g°ªP¦º¾¯¶qªºbungarotoxin [5]¡C¬Û¸û©ó§t§Üìªí¦ìªº¦X¦¨Ð`肽¡A«²Õ¬r¯À¬°§¹¾ãªº³D¬r³J¥Õ¡A¤£¦ý¤º§t¤F©Ò¦³ªº§Üìªí¦ì¡A¥B¨ã¦³»P¤ÑµM¬r¯À§ó¬Û¦üªºµ²ºc¡A¬O¤@ºØ§ó¦X¾Aªº¨ú¥N©Ê§K¬Ìì¡Cªñ´Á¥t¦³¬ã¨sÅã¥Ü¡A¥H12ºØ½¿½»³D¬ì³D¬rªºµuÁ寫¸g¬r¯À³J¥Õ½è§Ç¦C©Ò³]pªº«²Õ¬r¯À¶i¦æ°¨¤Ç§K¬Ì¡A§ó¥i¥H²£¥X¼s®Ä«¬ªº§Ü³D¬r¦å²M¡A¯à¦³®Ä¤¤©M16ºØ½¿½»³D¬ìªº³D¬r[6]¡F¦¹§K¬Ìì¤wµø¬°¶}µo¼s®Ä«¬§Ü³D¬r¦å²Mªº¦³®Äµ¦²¤¡C²Ä¤TºØ¦³¼ç¤Oªº´À¥N§K¬Ìì¬ODNA¬Ì]¡CÂǥѪ`®g°ò¦]¤uµ{DNA¨Ó²£¥Í§Ü³D¬r¦å²Mªº¥t¤@ºØµ¦²¤¡A¨ä³Ì¤jªºÀuÂI¬O§K¥h¤F¤Wz¤Æ¾Ç¦X¦¨©Î«²Õ¥Í²£ªºÁcº¾¨BÆJ¡A§Q¥Î°ò¦]ºj¶i¦æª`®g¡AÄâ±a³D¬r³J¥Õ½èªº°ò¦]©Î§Üìªí¦ì¥i¥Hª½±µ¨ë¿E¥Ö¤UªºTh2²ÓM¡A¶i¦Ó«P¨ÏB²O¤Ú²y²ÓM²£¥Í¥X§ÜÅé¡CWagstaff³Õ¤hµ¥¤Hªº¬ã¨sÅã¥Ü¡A¥HÄâ±a³D¬rª÷ÄÝ酶¡]SVMP¡^¦h§Üìªí¦ìªºDNAÁå¶i¦æ§K¬Ì«á²£¥Íªº¦å²M¤ñ°_¥H²Ê³D¬r§@¬°§K¬Ìì©Ò²£¥Íªº¦å²M¹ï¿÷Åì蝰¡]Echis ocellatus¡^³D¬r¦³§ó¨Îªº¤¤©M¯à¤O[7]¡C¥t¥~¡APergolizzi³Õ¤hµ¥¤Hµo²{¡AµL½×¬Oª½±µª`®g£\-cobratoxinªºDNA©Î¬O¥H«²Õ¸¢¯f¬rÄâ±aDNA·P¬V¤p¹«¡A¤p¹«¬Ò¯à100%³q¹L©s¥[©Ô²´Ãè³D¬rªº§ð¬r´ú¸Õ[8]¡C ¥xÆW»s³Æ§Ü³D¬r¦å²M¤w¦³¦Ê¦~ªº¾ú¥v[9¡A10]¡C¨´¤µ¡A¯e¯fºÞ¨î¸p¨C¦~¥i¥H¥Í²£4ºØÁ`¶qªñ¤¤d¾¯²Å¦XPIC/S GMP³W½dªº°ª«~½è§Ü³D¬r¦å²M¡A¥R¤À¨ÑÀ³°ê¤ºÂåÀø¨Ï¥Î¡A¦¨ªG´´µM¡C¥xÆW¨¬°¦a²y§øªº¤@û¡A°£¤F¥Í²£§Ü³D¬r¦å²M¥~¡A¤]¿n·¥ªº§ë¤J¬ã¨s¯à¶q¡A¥H´Á¯à¶}µo¨ã¼sªx¤¤©M®ÄªGªº·s«¬§Ü³D¬r¦å²M»s¾¯¡A¬°¸Ñ¨M¦¹¤@³Q©¿²¤ªº¼ö±a¯e¯fºÉ¤@¤À¤ß¤O¡C °Ñ¦Ò¸ê®Æ - Henry S. Experiments on the Preventive Inoculation of Rattlesnake Venom¡A physiol. 1887¡A 8(3-4)¡A 203-10.
- Calmette A. The treatment of animals poisoned with snakevenom by the injection of antivenomous serum [J]. Br Med J. 1896¡A 2¡A 399-400.
- C£¾ urin-Šerbec¡A V.; Délot¡A E.; Faure¡A G.; Saliou¡A B.; Gubenšek¡A F.; Bon¡A C.; Choumet¡A V. Antipeptide antibodies directed to the C-terminal part of ammodytoxin A react with the PLA2 subunit of crotoxin and neutralize its pharmacological activity. Toxicon. 1994¡A 32¡A 1337¡V1348.
- Ferreira¡A R.N.; Machado de Avila¡A R.A.; Sanchez¡A E.F.; Maria¡A W.S.; Molina¡A F.; Granier¡A C.; Chávez-Olórtegui¡A C. Antibodies against synthetic epitopes inhibit the enzymatic activity of mutalysin II¡A a metalloproteinase from bushmaster snake venom. Toxicon. 2006¡A 48¡A 1098¡V1103.
- Dolimbek¡A B.Z.; Atassi¡A M.Z. Protection against alpha-bungarotoxin poisoning by immunization with synthetic toxin peptides. Immunol. 1996¡A 33¡A 681¡V689.
- Guillermo de la Rosa¡A Felipe Olvera¡A Irving G. Archundia¡A Bruno Lomonte¡A Alejandro Alagón & Gerardo Corzo. Horse immunization with short-chain consensus £\-neurotoxin generates antibodies against broad spectrum of elapid venomous species. Nat Commun. 2019 Aug 13;10(1):3642.
- Wagstaff¡A S.C.; Laing¡A G.D.; Theakston¡A R.D.G.; Papaspyridis¡A C.; Harrison¡A R.A. Bioinformatics and multiepitope DNA immunization to design rational snake antivenom. PLoS Med. 2006¡A 3¡A e184.
- Ramos¡A H.R.; Junqueira-de-Azevedo¡A I.D.L.M.; Novo¡A J.B.; Castro¡A K.; Duarte¡A C.G.; Machado-de-Ávila¡A R.A.; Chavez-Olortegui¡A C.; Ho¡A P.L. A Heterologous Multiepitope DNA Prime/Recombinant Protein Boost Immunisation Strategy for the Development of an Antiserum against Micrurus corallines (Coral Snake) Venom. PLoS Negl. Trop. Dis. 2016¡A 10¡A e0004484.
- ³¯®¶´¡A»OÆW¤j¾ÇÂå¥Î²Óµß¦å²M¾Ç±Ð®v¹ï»OÆW¨¾¬Ìªº°^Äm¡G±q»OÆWÂå¾Ç·|Âø»x¦^ÅU¡]¤U¡^¡A´ººÖÂå°T¡A2017¦~¡A²Ä34¨÷²Ä¤E´Á¡A 1-13¶¡C
- ®}¶®²ú¡A§d¨Î»T¡A©P¯ª·©¡AÁ¤å´Ü¡A¾G¶®ªâ¡A¦¿¥¿ºa¡A¥xÆW§Ü³D¬r¦å²M»s³y¤§¦^ÅU»P®i±æ¡A¬Ì±¡³ø¾É¡A2013¦~¡A²Ä29¨÷¡A²Ä¤»´Á¡C
¤å/¹Ï¡G·P¬V¯g»P¬Ì]¬ã¨s©Ò¼BªÃøʬã¨s§U²z¡B¦¿¬f»T¬ã¨s§U²z¡BJ³Í³Ç¬ã¨s§U²z¡B§º©ô¬w°Æ¬ã¨sû
|
A2¥N½X¡G7_45200.5794675926-5696 ¤Þ¥Î
A2¥N½X¡G7_44349.7404398148-2308 ¤Þ¥Î
|
|
|
|
B1¼s§i¥N½X¡G0_44476.0181712963-2551 ¤Þ¥Î
|
B2¼s§i¥N½X¡G1_44476.018287037-2553 ¤Þ¥Î
|
|
|
|
²L½Í¨¾¬Ì¶¼¹¨â¤T¨Æ
2020.5.14
|
|
|
ª¾ÃÑÅý¤H§K©ó®£Äß¡AÅý§Ṳ́@°_¥H¡uŪ¡v§ð¬r¡B®¼¹L²Ä¤Gªi¡I
2020.3.20
|
|
|
¸z¹Dµß¤£¥i¤p¬Ý ¥i¹w´úÀù¯g±wªÌ¹ï§K¬ÌÀøªk¦¨®Ä
2019.6.14
|
|
|
¥xÆW¤H·U³Ü·U¦h¡@Â÷Àù·U¨Ó·Uªñ
2019.5.3
|
|
|
¹ï§ÜÀù¯g¡@«äºû3¤j¤É¯Å
2019.3.7
|
|
|
ªÀ·|ÅܾE»P°A´C¶Ç¬V¯fªºÂàÅÜ
2019.2.22
|
|
|
B3¼s§i¥N½X¡G2_44476.0183449074-2555 ¤Þ¥Î
|
B4¼s§i¥N½X¡G3_45200.5800115741-5697 ¤Þ¥Î
|
|
|
|
¦uÅ@¨àµ£°·±d¦¨ªø
2021.6.4
|
|
|
B5¼s§i¥N½X¡G4_45200.5802199074-5698 ¤Þ¥Î
|
B6¼s§i¥N½X¡G5_45200.5803240741-5699 ¤Þ¥Î
|
|
|
|
Copyright © §K³dÁn©ú
¥xÆW°·±d»Eµ¸©Ò´£¨Ñ¤§¸ê°T¡A¶È¨Ñ°Ñ¦Ò¡B¤À¨É»P¥æ¬y¡A¥»¯¸À³·íºÉ¤O´£¨Ñ¥¿½T¤§¸ê°T¡A°ß©Ò¸ü¸ê°T§¡¨Ó¦Û¥»¯¸¤§¨£¸Ñ»Pºô¸ô¸ê®Æ¾ã²z¡A¹ï¨ä§¹¾ã©Ê¡B§Y®É©Ê©M¥¿½T©Ê¤£°µ¥ô¦ó¾á«O¡C ¦p¦³¿ùº|©Î²¨©¿¡A¥»¯¸¤£t¥ô¦óªk«ß³d¥ô¡C¥ô¦ó¤H¦]«H¿à¦¹µ¥¸ê®Æ¦Ó°µ¥X©Î§ïÅܨMµ¦¡A¶·¦Û¦æ©Ó¾áµ²ªG¡C ¥»¯¸©Ò¦³¤º®e¡A¤½¶}¸ê°T¤ÎÂà¸ü¸ê®Æ/¹Ï¤ù¡A¦p¦³«IÅv½Ð¨Ó«H§iª¾¡C¦p»ÝÂà¸ü¤å³¹½Ðµù©ú¥X³B¡C
|
¥DÃD¤J¤f«Å§i |